Open AccessClinical significance of high‐mobility group box‐1 (HMGB1) in subjects with type 2 diabetes mellitus (T2DM) combined with chronic obstructive pulmonary disease (COPD)
Author(s) -
Huang Jiayi,
Zeng Tingting,
Tian Yongjian,
Wu Yang,
Yu Jianlin,
Pei Zihuan,
Tan Liming
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22910
Subject(s) - copd , medicine , type 2 diabetes mellitus , vital capacity , diabetes mellitus , gastroenterology , glycated hemoglobin , type 2 diabetes , risk factor , fibrinogen , cardiology , endocrinology , lung , lung function , diffusing capacity
Background Simple method to predict type 2 diabetes mellitus (T2DM) combined with chronic obstructive pulmonary disease (COPD) is in great need clinically. This study aims to assess the clinical significance of high‐mobility group box‐1 (HMGB1) in predicting T2DM combined with COPD in Chinese patients with T2DM or COPD. Methods Serum concentrations of glycated hemoglobin (HbA1C), fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐c), high‐density lipoprotein cholesterol (HDL‐c), C‐reactive protein (CRP), fibrinogen (FIB), HMGB1, white blood cell count (WBC), neutrophil% (NEU%), and lung function text such as forced expiratory volume 1/forced vital capacity (FEV1/FVC) and forced expiratory volume 1% predicted value (FEV1%pred) were measured in 126 T2DM patients, 118 COPD patients, 112 T2DM combined with COPD patients, and 120 healthy controls. Logistic regression was used to estimate the risk factors for T2DM combined with COPD. Results High‐mobility group box‐1 elevated in patients with T2DM combined with COPD, significantly higher than other subjects ( P < 0.05), and differences in HMGB1 also existed between patients with T2DM or COPD and healthy individuals ( P < 0.01). HMGB1 was positively correlated with HOMA‐IR, FBG, and HbA1c ( P < 0.01) and negatively correlated with FEV1/FVC and FEV1%pred ( P < 0.01). Logistic regression showed that HMGB1 was identified to be independent risk factor for T2DM combined with COPD. Conclusion High‐mobility group box‐1 was independent risk factor for T2DM combined with COPD and can be served to predict the occurrence of T2DM combined with COPD.