Open AccessSerum amylase activity altered by the ABO blood group system in Chinese subjects
Author(s) -
Peng YouFan,
Goyal Hemant,
Lin Hao,
Liu DeChen,
Li Ling
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22883
Subject(s) - abo blood group system , amylase , odds ratio , medicine , blood type (non human) , population , endocrinology , immunology , gastroenterology , biology , enzyme , biochemistry , environmental health
Objective The underlying interactions between ABO blood group antigens and pancreatic exocrine tissue have been demonstrated, and serum amylase was synthesized by pancreatic ductal cells. Thus, we investigated the link between ABO blood type and serum amylase activity in Chinese subjects. Methods Our study included 343 relatively healthy Chinese individuals, and the data were retrieved from electronic medical record database. Results A increased trend was observed for serum amylase activity in ABO blood type distribution, and we found that serum amylase activity was remarkable increased in subjects with O blood type compared to those with non‐O blood type ( P = 0.013). Logistic regression analysis indicated that serum amylase was independently associated with individuals with O blood group (adjusted odds ratio 1.574; 95% CI, 1.022‐2.425, P = 0.039). Conclusions The present evidence suggests a significant link between serum amylase activity and ABO blood type in the study population, indicating ABO blood type may be associated with the susceptibility of pancreatic disease.