Open AccessIDO and intra‐tumoral neutrophils were independent prognostic factors for overall survival for hepatocellular carcinoma
Author(s) -
Wang Yan,
Yao Rongrong,
Zhang Lan,
Xie Xiaoying,
Chen Rongxin,
Ren Zhenggang
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22872
Subject(s) - hepatocellular carcinoma , medicine , proportional hazards model , immunohistochemistry , immune system , oncology , infiltration (hvac) , carcinoma , milan criteria , tissue microarray , survival analysis , multivariate analysis , cancer research , immunology , liver transplantation , transplantation , physics , thermodynamics
Background Both Indole‐amine‐2,3‐dioxygenase (IDO) and neutrophils were proved to have pro‐tumor effect in some kinds of solid tumors by immune suppression. However, little is known about their effect on hepatocellular carcinoma (HCC) and the relationship between these two immune‐suppressive factors. The aim of this study was to evaluate the prognostic significance of IDO and intra‐tumoral neutrophils and their correlations in HCC. Methods Specimens’ tissue microarray (TMA) for 153 HCC patients was used in this study. We examined intra‐tumoral expression of IDO and CD66b in TMA. The Kaplan‐Meier method and Cox regression models were used to evaluate the prognostic value of IDO expression and CD66b. Results Multivariate analysis showed both IDO expression and intra‐tumoral neutrophils infiltration were independent prognostic factors for overall survival (OS). In high IDO expression group, the percentage of intra‐tumoral neutrophils infiltration was higher than that in low IDO expression group. Conclusion Both IDO and intra‐tumoral neutrophils were independent prognostic factors for overall survival for HCC.