Open AccessCorrelation between hematological parameters and ancylostomiasis: A retrospective study
Author(s) -
Hu Zuojian,
Chen Huaping,
Huang Li,
Chen Siyuan,
Huang Zhili,
Qin Shanzi,
Zhong Jianing,
Qin Xue,
Li Shan
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22705
Subject(s) - ancylostomiasis , medicine , gastroenterology , lymphocyte , immunology , helminths
Objective Our aim intended to determine the relationship between hematological parameters (neutrophil‐to‐lymphocyte ratio [NLR], platelet‐to‐lymphocyte ratio [PLR], and eosinophil‐to‐lymphocyte ratio [ELR]) and ancylostomiasis. Methods There were 140 patients with ancylostomiasis and 159 healthy controls enrolled in this study. All data were collected from electronic medical records of the First Affiliated Hospital of Guangxi Medical University. Results The levels of NLR, PLR, and ELR in ancylostomiasis patients were significantly higher than those in the healthy controls (all P = 0.000). A receiver operating characteristic curve was generated to assess the diagnostic efficacy of these three hematological parameters. ELR (AUC = 0.850; sensitivity = 75.00%; specificity = 86.80%) showed the superior AUC than those of NLR (AUC = 0.718; sensitivity = 53.57%; specificity = 88.68%) and PLR (AUC = 0.806; sensitivity = 68.57%; specificity = 86.79%), respectively. A multivariate regression model using the two selected indices (RBC and ELR) was established with the model's sensitivity and specificity reached 82.86% and 96.23%, respectively. In the ancylostomiasis patient group, NLR ( r = −0.452, P = 0.000) and PLR ( r = −0.357, P = 0.000) were reversely associated with eosinophils. Conclusion The pretreatment levels of the three hematological parameters (NLR, PLR, and ELR) may serve as valuable indicators for distinguishing patients with ancylostomiasis from healthy controls. NLR and PLR are negatively associated with the previous indicator, eosinophils.