Open AccessInterleukin‐7 gene polymorphism rs766736182 associates with the risk of asthma in children
Author(s) -
Cao Junhua,
Tian Lijun,
Li Zhenguang,
Zhang Chonglin,
Ji Qiang,
Zhang Chuanling,
Qian Tong
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22675
Subject(s) - asthma , snp , single nucleotide polymorphism , odds ratio , medicine , immunology , interleukin 13 , interleukin , gene , genetics , genotype , biology , cytokine
Background Recently studies uncovered associations between polymorphisms of interleukin genes and the risk of asthma. However, the relationship between polymorphisms of interleukin‐7 gene and the risk of children asthma has not been discovered yet. This study aims to investigate the relationship between single nucleotide polymorphisms ( SNP s) on interleukin‐7 gene and the risk of children asthma. Methods We genotyped eight SNP s of interleukin‐7 gene in blood samples from 437 asthma patients and 489 healthy controls to analyze potential associations of these SNP s with the risk of asthma in children. Results A missense SNP rs766736182 (odds ratio ( OR ) = 2.185, 95% confidence interval ( CI ) = 1.561‐2.252, P ‐value = 8.69468E‐19) of the interleukin‐7 gene is associated with the risk of children asthma. Conclusions This study reveals that SNP rs766736182 of interleukin‐7 is the risk factor for children asthma and implies potential role of immune system in the pathogenesis of children asthma.