Open AccessAssociation of HLA ‐ DQA 1 gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population
Author(s) -
Zhu Bingbing,
Zhang Ruifeng,
Yang Huandan,
Yuan Tingting,
Lv Juan,
Peng Qianqian,
Tian Lijun
Publication year - 2019
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22623
Subject(s) - single nucleotide polymorphism , odds ratio , snp , human leukocyte antigen , genetics , population , medicine , missense mutation , immunology , biology , gene , genotype , antigen , mutation , environmental health
Background The association between gene polymorphisms and the risk of primary nephrotic syndrome ( PNS ) is uncovering recently. This study aims to investigate the relationship between single nucleotide polymorphisms ( SNP s) on HLA ‐ DQA 1 gene and the risk of PNS . Methods In this study, we genotyped eight single nucleotide polymorphisms ( SNP s) in the HLA ‐ DQA 1 gene in 501 PNS patients and 532 healthy people in Chinese population. Then we analyzed associations of these SNP s with the clinical features in primary nephrotic syndrome of children in Chinese population. Results Significant associations with PNS were found on missense SNP rs1129740 ( GG vs AA , odds ratio ( OR ) = 1.987, 95% confidence interval ( CI ) = 1.468‐2.652, P = 0.00177049) and rs1047992 ( AA vs GG , OR = 1.857, 95% CI = 1.325‐2.391, P = 1.1073E‐10) of the HLA ‐ DQA 1 gene. Conclusions This work suggests SNP s of HLA ‐ DQA 1 are risk factors for PNS in Chinese population, which implies roles of immune response in the pathogenesis of PNS .