Open AccessIncreased plasma prothrombin time is associated with poor prognosis in patients with paraquat poisoning
Author(s) -
Hu Xiao,
Guo Renyong,
Chen Xing,
Chen Yu
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22597
Subject(s) - partial thromboplastin time , medicine , prothrombin time , thrombin time , fibrinogen , coagulation , gastroenterology , ingestion , univariate analysis , paraquat , coagulation testing , anesthesia , multivariate analysis , chemistry , biochemistry
Background Paraquat can cause severe injury to vascular endothelial cells and lead to coagulation dysfunction when it is taken into the blood by oral ingestion. In this study, we aim to find a routine coagulation index to serve as an indicator of outcome in patients with acute paraquat poisoning. Methods Between January 2012 and December 2016, 209 patients who attempted suicide by oral ingestion of paraquat were admitted to the emergency room. Routine coagulation indices, including plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fbg), thrombin time (TT), and D‐dimer were measured to analyze the trend of changes and their relationship with prognosis. Results The results showed that the PT and APTT values in the ≥30 mL group were significantly greater than those in the <30 mL group (both P < .01). Within 1 week of admission, PT and APTT values gradually decreased, while Fbg levels gradually increased. Univariate and multivariate Cox regression analysis indicated that sex, ingestion volume, and PT were independent predictors of mortality within 40 days. The cumulative survival rates differed significantly ( P = .001) between patients with PT <12 seconds and PT ≥12 seconds. Conclusions Coagulation status in patients with PQ poisoning was closely related to prognosis. Routine monitoring of coagulation function, particularly PT in plasma, is helpful for analysis of the condition and prognosis of patients with PQ poisoning.