Open AccessImmunophenotypes and clinical features of lymphocytes in the labial gland of primary Sjogren's syndrome patients
Author(s) -
Sun Wenwen,
Zhang Na,
Zhang Yujie,
Shao Zonghong,
Gong Lu,
Wei Wei
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22585
Subject(s) - erythrocyte sedimentation rate , salivary gland , medicine , antibody , immunophenotyping , lymphocyte , pathology , endocrinology , immunology , antigen
Objective To investigate consistency of lymphocyte immunophenotype between labial gland and peripheral blood in patients with primary Sjogren's syndrome ( pSS ). Methods Seventy‐one pSS patients and 35 patients with maxillofacial trauma were included in the study. Based on the ratio of CD 20 to CD 3 in labial gland from 71 pSS patients, they were divided into the high and (n = 48) and low CD 20 expression group (n = 23). Lymphocyte immunophenotypes in labial glands, course of disease, erythrocyte sedimentation rate ( ESR ), C‐reactive protein, immunoglobulin, and complement levels were analyzed. Results In the labial gland, the levels of IgG, IgA, IgM, and C3c were higher, but C1q was lower in the pSS group than in the control group (all P < .05). CD 20 was detected in labial gland samples of all pSS patients, in which CD 3 was positive in 66 (93.0%) patients, and negative in 5 (7.0%). The plasma levels of IgG, IgA, IgM, and CRP , and ESR were higher, but serum C4 level was lower in pSS patients than in the control group (all P < .01). Serum IgG level, ESR , and labial gland CD 20 were higher in the high CD 20 expression group than the low expression group (all P < .05). Conclusion Primary Sjogren's syndrome patients had a higher expression of CD 20 positive infiltrating lymphocytes of the labial gland, accompanied with the changes of immunoglobulins, and complements in both the labial gland and peripheral blood.