Open AccessDecreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma
Author(s) -
Lan Xiabin,
Cao Jun,
Xu Jiajie,
Chen Chao,
Zheng Chuanming,
Wang Jiafeng,
Zhu Xuhang,
Zhu Xin,
Ge Minghua
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22573
Subject(s) - thyroid carcinoma , malignancy , receiver operating characteristic , circular rna , carcinogenesis , biomarker , lymph node , downregulation and upregulation , rna , thyroid cancer , medicine , carcinoma , cancer research , pathology , cancer , thyroid , chemistry , gene , biochemistry
Background Circular RNA (circ RNA ) is a new type of noncoding RNA that can serve as ideal biomarkers. Evidence has showed that circ RNA s play an important role in carcinogenesis and cancer development. However, little is known about the diagnostic value of circ RNA s in papillary thyroid carcinoma ( PTC ) as well as their associations with clinicopathologic characteristics of patients with PTC . Methods The expression levels of hsa_circ_0137287 were detected in 120 PTC and 60 adjacent noncancerous thyroid tissues by quantitative real‐time polymerase chain reaction. The relationships between the expression of hsa_circ_0137287 in PTC and the clinicopathologic factors were analyzed. Finally, receiver operating characteristic ( ROC ) curves were generated to assess the diagnostic value of hsa_circ_0137287 as a biomarker for PTC . Results The expression of hsa_circ_0137287 was significantly downregulated in PTC tissues compared with adjacent noncancerous tissues ( P < .0001). Downregulation of hsa_circ_0137287 correlated with aggressive clinicopathologic characteristics of PTC such as extrathyroidal extension ( P < .001), lymph node metastasis ( P = .022), advanced T stage ( P < .001) and larger tumor size ( P < .001). The ROC curves revealed that hsa_circ_0137287 had a potential diagnostic value in predicting malignancy, extrathyroidal extension and lymph node metastasis. The area under curves were 0.8973 (95% CI = 0.8452‐0.9494, P < .0001), 0.6885 (95% CI = 0.5908‐0.7862, P = .0009), and 0.6691(95% CI = 0.5641‐0.7742, P = .0034), respectively. Conclusions Our findings suggest that hsa_circ_0137287 may serve as a novel biomarker for PTC .