Open AccessEvaluation of the clinical application of multiple tumor marker protein chip in the diagnostic of lung cancer
Author(s) -
Wang Xiaochuan,
Zhang Yi,
Sun Liangqi,
Wang Shuaiping,
Nie Jing,
Zhao Wenqing,
Zheng Guobao
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22565
Subject(s) - lung cancer , adenocarcinoma , medicine , tumor marker , lung , carcinoma , protein chip , cancer , pathology , ferritin , oncology , gastroenterology , biology , bioinformatics
Background The early diagnostic of lung cancer plays an important role in the prognosis of surgical treatment among lung cancer patients. To evaluate the clinical application of multi‐tumor markers protein biochip in the diagnosis of lung cancer, 12 tumor markers were detected in patients with different stages of lung cancer. Methods Serum CA 125, CA 19‐9, Ferritin, CA 15‐3, CA 242, CEA , AFP , NSE , PSA , f‐ PSA , HGH , and β‐ HGH were assessed in 506 patients, with 224 patients with lung cancer (including 123 cases of adenocarcinoma, 30 squamous cell carcinoma, 54 small‐cell carcinoma, and 17 non classification), 159 patients with benign lung disease and 90 healthy people control by the C‐12 multiple tumor protein‐chip detective system. Results The positive rate of C‐12 (77.23%) in lung cancer was significantly higher than that of benign lung disease (13.84%) and healthy people (9.76%) ( P < .01). In lung cancer, the positive rate of CA 199, NSE , CEA , CA 242, Ferritin, f‐ PSA , and CA 125 were significantly higher than that of benign lung disease and healthy people. In adenocarcinoma, the positive rate of CA 125 (73.53%) was significantly higher than that of squamous cell carcinoma (36.67%) and small‐cell carcinoma (56.62%). Conclusion The C‐12 multiple tumor protein‐chip detective system has acceptable sensitivity in the diagnostic of lung cancer.