Open AccessAssociation between the XPG gene rs2094258 polymorphism and risk of gastric cancer
Author(s) -
Zhang Zhe,
Yin Jiefeng,
Xu Qi,
Shi Jianfeng
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22564
Subject(s) - xeroderma pigmentosum , genetics , biology , genomic dna , gene polymorphism , gene , meta analysis , genotype , polymerase chain reaction , population , microbiology and biotechnology , dna repair , medicine , environmental health
Background Xeroderma pigmentosum group G ( XPG ) plays an important role in maintaining the stability and integrity of genomic DNA . Previous studies demonstrate some XPG gene polymorphisms are associated with susceptibility to gastric cancer ( GC ). Methods The association between XPG rs2094258 polymorphism and GC risk was investigated first by a hospital‐based case‐control study involving 386 patients and 439 controls and then by a meta‐analysis. The polymorphism was genotyped by polymerase chain reaction‐restriction fragment length polymorphism ( PCR ‐ RFLR ). Results Xeroderma pigmentosum group G rs2094258 polymorphism was associated with an increased risk of GC in a Chinese population. The meta‐analysis did not reveal any significant difference in the overall population. Subgroup analysis of geographic locations showed a significant association between the XPG gene rs2094258 polymorphism and GC risk in Southern China. Stratification analysis further indicated significant associations in hospital‐based studies and studies using PCR ‐ RFLR . Conclusion Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of GC in Southern China. Nevertheless, the findings of this meta‐analysis should be validated by well‐designed large‐scale case‐control studies among other ethnicities.