Open AccessRelationship between C‐reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris
Author(s) -
Karabağ Yavuz,
Çağdaş Metin,
Rencuzogullari Ibrahim,
Karakoyun Süleyman,
Artaç İnanç,
İliş Doğan,
Atalay Eray,
Yesin Mahmut,
Gürsoy Mustafa Ozan,
Halil Tanboğa Ibrahim
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22457
Subject(s) - c reactive protein , medicine , coronary artery disease , albumin , cardiology , angina , gastroenterology , inflammation , myocardial infarction
Background Syntax score ( SS ), which is an angiographic tool used in grading the complexity of coronary artery disease ( CAD ), has prognostic importance in coronary artery disease ( CAD ) and provides important information regarding selection of revascularization strategy. C‐reactive protein ( CRP ) and albumin are indicators of inflammation, and high levels of them are associated with high SS . We aimed to investigate whether baseline CRP to albumin ratio C‐Reactive Protein/Albumin Ratio ( CAR ), an easily available and novel inflammatory marker, is associated with SS . Method A total 403 consecutive patients with stabile angina pectoris, who underwent coronary angiography for suspected CAD from January 2015 to June 2016, were classified into two groups, low SS (≤22) and intermediate‐high SS (>22). Results C‐Reactive Protein/Albumin Ratio was significantly higher in patients with intermediate‐high SS group ( P < .001). In multivariate regression analysis, CAR remained an independent predictor of intermediate‐high SS group together with hypertension and LDL . The predictive performance of CAR , CRP , and albumin was compared by ROC curve analysis. CAR surpassed CRP and albumin in predicting intermediate‐high SS group. CAR >6.3 predicted an intermediate‐high SS with sensitivity and specificity of 86.8% and 43.4%, respectively. Conclusion C‐Reactive Protein/Albumin Ratio was more tightly associated with the complexity and severity of CAD than CRP and albumin alone and was found to be an independent predictor for intermediate‐high SS group.