Open AccessPlatelet to lymphocyte ratio in acute aortic dissection
Author(s) -
Sbarouni Eftihia,
Georgiadou Panagiota,
Kosmas Elias,
Analitis Antonis,
Voudris Vassilis
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22447
Subject(s) - medicine , aortic dissection , red blood cell distribution width , lymphocyte , gastroenterology , platelet , dissection (medical) , aortic aneurysm , cardiology , neutrophil to lymphocyte ratio , surgery , ascending aorta , aorta
Background Inflammation plays an important role in the initiation and progression of acute aortic dissection ( AAD ). New inflammatory indices derived from full cell blood count and its differential may be associated with increased risk. We evaluated platelet‐lymphocyte ( PLR ), red cell distribution width ( RDW ) and RDW / PLT 's (platelets) ( RPR ) in AAD . Methods We studied 120 consecutive patients with AAD type I admitted for emergency surgery (group I), 121 consecutive patients with aortic aneurysms of the ascending aorta prior to elective repair (group II ) and 121 controls (group III ), age and sex matched. Results PLR was significantly higher in group I vs both groups II and III ( P < .001). There was an excellent correlation of PLR with neutrophil/lymphocyte ratio ( NLR ) in all three groups ( P < .001 for all). After adjustment for hemoglobin, RDW did not differ but RPR remained significantly higher in group I compared to groups II and III ( P < .001). The best cutoff value of PLR to predict dissection was 159 with 53% sensitivity and 86% specificity. No association between PLR , RDW , and RPR and mortality in group I was found. Conclusions Indices derived from full cell blood count may provide diagnostic information in patients with AAD ; whether these indices may contribute to prognosis assessment should be further investigated.