Significant association between RGS 14 rs12654812 and nephrolithiasis risk among Guangxi population in China

Background Nephrolithiasis is a worldwide health problem that affects almost all populations. This study aimed to evaluate the association between rs12654812 of regulator of G protein signaling 14 ( RGS 14) gene and nephrolithiasis in the Chinese population. Methods A total of 1541 participators including 830 cases and 711 controls were included from Guangxi area in China. Age, sex, BMI , smoking status, drinking status, creatinine, uric acid, and urea nitrogen were analyzed between the case group and control group. Results We found that the G/A+A/A genotypes of rs12654812 had a significantly increased nephrolithiasis risk after adjusting age, sex, BMI , smoking, drinking, and hypertension, compared with G/G genotype ( OR  = 1.361, 95% CI  = 1.033‐1.794, P  = .029). This hazardous effect was more pronounced in subgroup of age < 50, ever smoking, ever drinking, creatinine normal, and high uric acid. The G/A genotype of rs12654812 also had a significantly increased nephrolithiasis risk compared with G/G genotype. The A allele of rs12654812 significantly increased the risk of nephrolithiasis compared with the G allele after adjusting for age, sex, BMI, smoking, drinking and hypertension ( OR  = 1.277, 95% CI  = 1.013‐1.609, P  = .038). Conclusions Our results suggest that the RGS 14 polymorphism is involved in the etiology of nephrolithiasis and thus may be a genetic marker for nephrolithiasis.