Open AccessThe CDKN 2A polymorphisms and the susceptibility of HBV ‐related gestational diabetes mellitus
Author(s) -
Wang Shuzhen,
Liu Jie,
Wang Qiaolian,
Du Jianguo,
Wang Beibei
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22423
Subject(s) - gestational diabetes , genotype , single nucleotide polymorphism , genotyping , medicine , diabetes mellitus , snp , gastroenterology , immunology , pregnancy , biology , gestation , genetics , endocrinology , gene
Background Single‐nucleotide polymorphisms ( SNP s) were discovered in HBV ‐related gestational diabetes mellitus, but it still unclear whether these SNP s are associated with the susceptibility of HBV ‐related gestational diabetes mellitus. Methods The investigation of the association between CDKN 2A polymorphisms and occurrence of HBV ‐related gestational diabetes mellitus ( GDM ) in Chinese was assessed in the case‐control study. A total of 480 pregnant patients with HBV and 530 pregnant controls were consecutively recruited from January 2015 to December 2016. Polymerase chain reaction‐restriction fragment length polymorphisms ( PCR ‐ RFLP ) method was applied to measure genotyping for the detection of CDKN 2A. Results The significant differences in the frequency of CDKN 2A genotype distributions, rs10811661 and rs564398, were found by Chi‐square test. Using conditional logistic analysis, individuals carrying the CDKN 2A rs10811661 TC and TT genotypes and CDKN 2A rs564398 AA and AG genotypes were related to a greater risk of HBV ‐related GDM compared with the genotype. Conclusions In conclusion, the CDKN 2A rs10811661 and rs564398 polymorphisms showed association with a greater risk of HBV ‐related GDM in a Chinese population.