Plasma CXCL 1 levels and TRAF 3 IP 2 variants in patients with myocardial infarction

Background IL ‐17A plays an important role in inflammatory responses in myocardial infarction ( MI ). IL ‐17A signals through its receptor, for which, Act1 ( TRAF 3 IP 2) functions as a key upstream adaptor in the pathway. Aim To compare frequencies of functional polymorphisms of TRAF 3 IP 2 (rs13210247, rs33980500) between patients with MI and healthy controls. Methods The selected SNP s were studied in 201 Iranian MI patients and 201 healthy blood donors from Fars Province by PCR ‐ RFLP in association with clinicopathologic criteria of patients. CXCL 1 plasma levels in 126 MI patients and 50 normal subjects were measured by ELISA . Results A significant increase in the mutant (T) allele of TRAF 3 IP 2 rs33980500 in patients with diastolic dysfunction of the heart ( P  = .01) was observed. The highest correlation, however, was observed between the TRAF 3 IP 2 rs33980500 TT genotype and T allele with left main coronary artery stenosis ( P  = .01, P  < .001; OR  = 31.03). T allele of TRAF 3 IP 2 rs33980500 was also associated with female gender, family history of cardiovascular disease, and mechanical complications of heart ( P  = .04, P  = .02, and P  = .01, respectively). Moreover, TRAF 3 IP 2 rs13210247 (G) correlated with mechanical complications of the heart ( P  = .01). A significant increase in the plasma levels of CXCL 1 chemokine in patients ( P  = .0006) associated with TT genotype of TRAF 3 IP 2 (rs33980500) was observed ( P  = .04). Conclusion The gene variants of Act1 adaptor are associated with correlates of poor outcome in patients with MI and plasma CXCL 1 levels.