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Reference intervals of carbohydrate antigen 19‐9 in the apparently healthy adult population
Author(s) -
Zhang GaoMing,
Bai ShuMei,
Zhang GuoMing,
Ma XiaoBo
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22380
Subject(s) - confidence interval , reference values , medicine , guideline , population , age groups , demography , pathology , environmental health , sociology
Background To establish reference intervals of carbohydrate antigen 19‐9( CA 19‐9) according to the CLSI CA 28‐A3 guideline and to evaluate age‐ and gender‐related variations. Methods Serum CA 19‐9 values of 10 149 healthy subjects (from 20 years old to 60 years old) were measured from location health checkups. The relationship between CA 19‐9 and age was analyzed using Spearman's approach. The reference intervals of CA 19‐9 were established using Q 2.5 and Q 97.5 , and the 90% confidence intervals of upper limits were calculated. Results The reference intervals of CA 19‐9 were 1.98‐25.12 U/mL for males (1.97‐25.06 U/mL for 20‐50 years old and 2.31‐26.13 U/mL for 50‐60 years old) and 2.36‐29.29 U/mL for adult (20‐60 years old) females. The upper limit of reference intervals for all individuals was 26.45 U/mL; the level of CA 19‐9 is higher in females than males. Carbohydrate antigen ( CA ) 19‐9 is significantly associated with aging in adult males( r  = .0930, P <  .0001), but not in females ( P  = .4734). Conclusions Establishing reference intervals for CA 19‐9 and giving age‐related reference intervals of CA 19‐9 using a big data of healthy adult, we first discovered that CA 19‐9 tends to increase with age in adult males but not in females.

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