Open AccessBiological variation of serum neuron‐specific enolase and carbohydrate antigen 724 tumor markers
Author(s) -
Wang Shuo,
Zhao Min,
Mu Runqing,
Zhang Xin,
Yun Ke,
Shang Hong
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22327
Subject(s) - enolase , antigen , biology , carbohydrate , medicine , pathology , endocrinology , immunology , biochemistry , immunohistochemistry
Background The aim of our study was to assess two tumor markers, carbohydrate antigen 724 ( CA 724) and neuron‐specific enolase ( NSE ), in 20 healthy individuals. Then, we determined their average intra‐ and inter‐individual biological variations ( CV I and CV G ). Methods Blood samples were taken at weekly intervals for five weeks from 20 healthy subjects through a detailed questionnaire and physical examination. These samples were stored at −80°C and analyzed in a single run in duplicate. We calculated the biological variations, the reference change value ( RCV ), and the index of individuality ( II ) for the two tumor markers. Results The intra‐individual and inter‐individual biological variations were 50.3% and 103.4% for CA 724, and 10.1% and 12.0% for NSE , respectively. The II values for CA 724 and NSE were 0.48 and 0.85, respectively. Conclusion We determined the biological variations and indices of individuality for CA 724 and NSE among 20 healthy subjects. These results will improve clinical applications of the markers.