Open AccessMultiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations
Author(s) -
Chen Jie,
Li Lixin,
An Yunfei,
Zhang Junlong,
Liao Yun,
Li Yi,
Wang Lanlan
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22308
Subject(s) - stat protein , stat , allele , immunology , biology , medicine , stat3 , genetics , signal transduction , gene
Objectives Posttransplantation diabetes mellitus ( PTDM ) is a major complication after solid organ transplantation. This study is to investigate the association of nine genetic variant factors and PTDM in Chinese Han patients. Methods HLA ‐ DP (rs3077, rs9277535), HLA ‐ DQ (rs7453920), signal transducer and activator of transcription 4 ( STAT 4) (rs7574865), IL ‐28B (rs12979860, rs8099917, and rs12980275), and IL ‐18 (rs1946518 and rs187238) were investigated in 260 liver transplant recipients ( PTDM vs non‐ PTDM ) by high‐resolution melting curve analysis. Serum interleukin ( IL )‐1β, IL ‐6, IL ‐8, IL ‐17, interferon‐γ, inducible protein‐10, monocyte chemoattractant protein‐1, and macrophage inflammatory protein‐1b were analyzed by a Bio‐Plex suspension array system (Bio‐Plex Multiplex Immunoassays, Bio‐Rad, Hercules, CA, USA). Results Signal transducer and activator of transcription 4 (rs7574865) T allele and IL ‐18 (rs1946518) A allele increase the risk for insulin resistance and PTDM . Conclusions Recipients with STAT 4 (rs7574865) T allele are associated with an increased concentration of IL ‐1β, interferon‐γ, monocyte chemoattractant protein, and macrophage inflammatory protein‐1b. The genetic variants of STAT 4 (rs7574865) and IL ‐18 (rs1946518) may be new important markers for PTDM .