Open AccessIdentification of sequence polymorphisms in the mitochondrial cytochrome c oxidase genes as risk factors for hepatocellular carcinoma
Author(s) -
Wang Hongfang,
Xu Jinsheng,
Li Demao,
Zhang Shenglei,
Guo Zhanjun
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22299
Subject(s) - single nucleotide polymorphism , snp , mitochondrial dna , hepatocellular carcinoma , biology , gene , genetics , coding region , allele , genotype , microbiology and biotechnology , medicine
Background Single nucleotide polymorphisms ( SNP s) accumulated in the mitochondrial DNA (mt DNA ) is susceptible to the tumor formation. We discovered previously that SNP s in the mitochondrial displacement loop (D‐loop) was associated with the risk of hepatocellular carcinoma ( HCC ). Methods The cytochrome c oxidase ( COX ) genes of mt DNA were sequenced between 107 HCC patients and 100 matched healthy controls. The χ 2 test was used to analyze single SNP s’ statistical difference between HCC patients and healthy controls. Results In this study, cancer risk‐associated SNP s in the COX genes of mt DNA coding region were assessed in HCC patients and health controls. The nucleotide position at site 9545A/G ( P=.036) was identified its association for HCC with the 9545G allele susceptible to cancer risk. Conclusions The SNP s in the COX genes may help us to evaluate the cancer risk of HCC .