Open AccessReduced expression of circ RNA hsa_circ_0003159 in gastric cancer and its clinical significance
Author(s) -
Tian Mengqian,
Chen Ruoyu,
Li Tianwen,
Xiao Bingxiu
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22281
Subject(s) - cancer , circular rna , rna , stage (stratigraphy) , receiver operating characteristic , metastasis , cancer research , real time polymerase chain reaction , reverse transcription polymerase chain reaction , messenger rna , distant metastasis , medicine , oncology , pathology , biology , gene , biochemistry , paleontology
Background Circular RNA s (circ RNA s) play a crucial role in the occurrence of several diseases including cancers. However, little is known about circ RNA s’ diagnostic values for gastric cancer, one of the worldwide most common diseases of mortality. Methods The hsa_circ_0003159 levels in 108 paired gastric cancer tissues and adjacent non‐tumorous tissues from surgical patients with gastric cancer were first detected by real‐time quantitative reverse transcription‐polymerase chain reaction. Then, the relationships between hsa_circ_0003159 expression levels in gastric cancer tissues and the clinicopathological factors of patients with gastric cancer were analyzed. Finally, its diagnostic value was evaluated through the receiver operating characteristic curve. Results Compared with paired adjacent non‐tumorous tissues, hsa_circ_0003159 expression was significantly down‐regulated in gastric cancer tissues. What is more, we found that hsa_circ_0003159 expression levels were significantly negatively associated with gender, distal metastasis, and tumor‐node‐metastasis stage. Conclusions All of the results suggest that hsa_circ_0003159 may be a potential cancer marker of patients with gastric cancer.