z-logo
open-access-imgOpen Access
Clinical implications of pretreatment inflammatory biomarkers as independent prognostic indicators in prostate cancer
Author(s) -
Sun Zhaohui,
Ju Ying,
Han Fuyan,
Sun Xiya,
Wang Fang
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22277
Subject(s) - medicine , red blood cell distribution width , prostate cancer , neutrophil to lymphocyte ratio , oncology , gastroenterology , lymphocyte , cancer
Objectives Research on the relationship between inflammatory biomarkers and malignant tumors has become a hotspot. Many studies have demonstrated that neutrophil‐lymphocyte ratio ( NLR ), platelet‐lymphocyte ratio ( PLR ), and red blood cell distribution width ( RDW ) could act as independent prognostic indicators for several solid tumors. This study aimed to evaluate the clinical implications of pretreatment inflammatory biomarkers, including NLR , PLR , and RDW as independent prognostic indicators in prostate cancer ( PC a). Methods A total of 226 PC a patients who were diagnosed at our institution from 2011 to 2016 were analyzed retrospectively. We compared the clinicopathological features, survival curves, and prognosis of the PC a patients between the high and low groups according to the cutoffs of NLR , PLR , and RDW . Results The pretreatment NLR , PLR , and RDW values were significantly higher in the patients with PC a than those in the controls ( P <.05). Increased NLR and PLR values were significantly associated with high risk of progression, including higher Gleason scores, cell proliferation antigen 67 (Ki‐67) indexes, and prostate‐specific antigen ( PSA ) levels ( P <.05), whereas an elevated RDW was only associated with an older age. An increased NLR was correlated with both overall survival ( OS ) ( P =.025) and disease‐free survival ( DFS ) ( P =.017). In addition, a higher PLR only showed a significantly worse DFS ( P =.040). Pretreatment NLR was an independent prognostic indicator of DFS . Conclusions The pretreatment NLR and PLR might be beneficial to predict the progression and prognosis of PC a. Furthermore, NLR was more effective than PLR acting as an independent prognostic indicator for PC a.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here