Open AccessPlasma serotonin level is a predictor for recurrence and poor prognosis in colorectal cancer patients
Author(s) -
Xia Yan,
Wang Dawei,
Zhang Nan,
Wang Zhihao,
Pang Li
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22263
Subject(s) - colorectal cancer , serotonin , medicine , biomarker , oncology , multivariate analysis , gastroenterology , cancer , metastasis , receiver operating characteristic , biology , receptor , biochemistry
Aim To investigate the prognostic value of plasma serotonin levels in colorectal cancer ( CRC ). Patients and Methods Preoperative plasma serotonin levels of 150 healthy control ( HC ) cases, 150 benign colorectal polyp ( BCP ) cases, and 176 CRC cases were determined using radioimmunoassay assay. Serotonin levels were compared between HC , BCP , and CRC cases, and those in CRC patients were related to 5‐year outcome. Results Plasma serotonin levels were markedly higher in CRC patients than in either HC s or BCP cases. An elevated serotonin level was significantly associated with advanced tumor node metastasis. Receiver operating characteristic curve analysis showed that the level of serotonin had a high predictive value for disease recurrence and mortality. Multivariate analysis revealed that high serotonin level was significantly associated with poor recurrence‐free survival and overall survival. Conclusion Our results suggest that a high peri‐operative plasma serotonin level is useful as a prognostic biomarker for CRC recurrence and poor survival.