Open AccessRNASET 2 , GPR 174 , and PTPN 22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves’ disease
Author(s) -
Zhang Qing,
Liu Shaozheng,
Guan Yanxing,
Chen Qingjie,
Zhang Qing,
Min Xiang
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22258
Subject(s) - snp , genotype , allele , single nucleotide polymorphism , logistic regression , medicine , gastroenterology , risk factor , immunology , gene , biology , genetics
Objectives This study was designed to unveil the association of GPR 174 rs3827440, PTPN 22 rs3789604, and RNASET 2 rs9355610 with the onset of liver damage ( LD ) among the Graves’ disease ( GD ) patients. Methods A total of 120 GD patients were divided into the none‐ LD and LD groups. Several indicators were detected for assessing liver functions, and genotypes of single nucleotide polymorphisms ( SNP s) were identified. Logistic regression was introduced for investigating the relationship between risk SNP s and LD ‐associated hyperthyroidism in GD patients. Results Significant differences were identified between LD and none‐ LD groups regarding genotype distributions of rs3827440, rs3789604, and rs9355610. Results from logistic regression indicted that among the GD patients, C carriers of PTPN 22 rs3789604 were associated with a higher risk of LD ‐associated hyperthyroidism, while C carriers of rs3827440 ( GPR 174 ) and G carriers of rs9355610 ( RNASET 2) were associated with a reduced risk of LD ‐associated hyperthyroidism. Conclusions The C allele of rs3789604 ( PTPN 22 ) was a significant risk factor for LD ‐associated hyperthyroidism in GD patients, whereas C allele of GPR 174 rs3827440 and G allele of RNASET 2 rs9355610 appeared to be a protective factor for this disease.