Open Access
Routine hematological parameters are associated with short‐ and long‐term prognosis of patients with ischemic stroke
Author(s) -
Fan Luo,
Gui Li,
Chai ErQing,
Wei ChaoJun
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22244
Subject(s) - medicine , red blood cell distribution width , eosinophil , white blood cell , receiver operating characteristic , neutrophil to lymphocyte ratio , logistic regression , proportional hazards model , lymphocyte , stroke (engine) , gastroenterology , area under the curve , mechanical engineering , asthma , engineering
Background Previous studies indicated that some routine hematological parameters are associated with the prognosis of ischemic stroke ( IS ), but none of study has evaluated them simultaneously. The aim of this study was to investigate the prognostic value of routine hematological parameters in IS patients. Methods Using medical record database, we retrospectively reviewed the patients with IS admitted in Gansu Province Hospital between June 2014 and July 2015. The prognostic value of routine hematological parameters on admission was analyzed using logistic regression model, receiver operating characteristic ( ROC ) curve analysis and Cox proportional hazards model. Results Patients with hospital mortality had significantly higher white blood cell ( WBC ), neutrophil, neutrophil to lymphocyte ratio ( NLR ), red blood cell distribution width ( RDW ) and National Institutes of Health Stroke Scale ( NIHSS ), while their lymphocyte, monocyte, and eosinophil were significantly lower. The area under ROC curve ( AUC ) for eosinophil, neutrophil, WBC , RDW , NLR , monocyte, and lymphocyte were 0.74 (95% CI , 0.67‐0.82), 0.76 (95% CI , 0.67‐0.84), 0.72 (95% CI , 0.64‐0.81), 0.65 (95% CI , 0.56‐0.73), 0.76 (95% CI , 0.68‐0.84), 0.67 (95% CI , 0.59‐0.76), and 0.75 (95% CI , 0.67‐0.83), respectively. In a multivariable logistical regression model, only WBC , NLR , and NIHSS were independently associated with hospital mortality. In a multivariable model, age, NIHSS , RDW , NLR , and eosinophil were independent prognostic factors for all‐cause mortality. Conclusion Red blood cell distribution width, NLR and eosinophil are independent prognostic factors for IS .