Open AccessGlycated albumin is stable in plasma when exposed to common laboratory conditions and comparable when drawn from venous or capillary sites
Author(s) -
Reynolds Andrew N.,
Harper Michelle,
Venn Bernard J.,
Mann Jim
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22236
Subject(s) - albumin , venous blood , chemistry , glycated haemoglobin , serum albumin , medicine , human albumin , chromatography , diabetes mellitus , endocrinology , type 2 diabetes
Background Circulating glycated albumin is a marker of blood glucose reflecting the previous 2 weeks. However, the effects of storage conditions and draw site on glycated albumin values are not fully understood. Methods Fifteen plasma samples from people with type 2 diabetes were assessed during repeated freeze‐thaw rounds for 10 cycles. A further 15 samples were stored at 4°C and assessed over 3 days. Another 40 samples drawn concurrently from capillary and venous sites had their glycated albumin content compared. Results Glycated albumin concentration did not alter over 10 freeze‐thaw cycles ( P =.856), or after 72 hours at 4°C ( P =.962). Capillary and venous samples did not differ in their percentage of glycated albumin ( P =.379), although lower concentrations of albumin and glycated albumin (g/dL) were observed in the capillary sample ( P <.001). Conclusion Glycated albumin in plasma appears relatively stable when exposed to common laboratory conditions, reducing a potential confounder to its use as a marker of blood glucose control. The glycated albumin (%) in samples from capillary and venous sites was comparable, suggesting the potential of rapid or portable assessment devices that require a finger prick.