Open AccessDifferent free prostate‐specific antigen to total prostate‐specific antigen ratios using three detecting systems
Author(s) -
Huang HuiQing,
Zhang Yan,
Xu HuaGuo
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22231
Subject(s) - prostate specific antigen , heterophile , prostate , immunoassay , urology , medicine , prostate cancer , antigen , antibody , hyperplasia , cancer , immunology
Background Prostate‐specific antigen ( PSA ) is used as an indicative marker of a pathologic condition of the prostate, and the ratio of free PSA ( fPSA ) to total PSA ( tPSA ) helps to distinguish benign prostatic hyperplasia ( BPH ) from prostate cancer ( PC a). In this study, we present some reversed ratios of fPSA to tPSA and analyze the possible mechanism. Methods Using the UniCel DxI800 Access Immunoassay System, eight reversed fPSA to tPSA ratios were obtained, and then these samples were retested with an Abbott Architect i2000 Immunoassay Analyser and Cobas e602. Results Four of the eight reversed ratios kept a ratio >1 using Abbott Architect i2000, and seven of them turned into a ratio <1 using Cobas e602. Conclusion In consideration of the assay these three detecting systems apply, the possible reason of the reversed ratios can be heterophile antibodies. To get accurate reason, further study is required.