Open AccessDeterminant roles of gender and age on SII , PLR , NLR , LMR and MLR and their reference intervals defining in Henan, China: A posteriori and big‐data‐based
Author(s) -
Meng Xianchun,
Chang Qian,
Liu Yuying,
Chen Ling,
Wei Gaohui,
Yang Jingjing,
Zheng Peiguo,
He Fucheng,
Wang Wanhai,
Ming Liang
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22228
Subject(s) - medicine , cohort , demography , age groups , sociology
Objectives By now, there are few data of the reference intervals ( RI s) of SII , PLR , NLR , LMR and MLR . We aimed to establish RI s of SII , PLR , NLR , LMR and MLR for healthy persons. Methods A retrospective analysis on a cohort of ostensibly healthy, aged no <18 years old physical examinees who took health examination from January to December in 2013 was conducted to explore influences of age and gender on SII , PLR , NLR , LMR and MLR and to establish their RI s. And another cohort of 450 persons in our hospital from January to July in 2016 is included for validations of RI s. Results NLR , LMR and MLR were significantly different between gender groups ( P =.010; P <.001; P <.001, separately), while SII and PLR were not ( P =.137; P =.267, separately). While SII was not changed much between age groups ( P =.842), PLR , NLR , LMR and MLR were significantly different (all with P <.001). RI s of SII , PLR , NLR , LMR and MLR were: SII : [161,701]; PLR : 18‐65 year‐old: [61,179]/>65 year‐old: [55,179]; NLR : 18‐65 year‐old male: [0.90,2.94]/18‐65 year‐old female: [0.85,3.06]/>65 year‐old male: [0.95,3.57]/aged >65 year‐old female: [0.83,3.30]; LMR : 18‐65 year‐old male: [2.50,7.50]/18‐65 year‐old female: [2.75,8.50]/>65 year‐old male: [2.16,7.41]/>65 year‐old female: [2.40,8.33]; MLR : 18‐65 year‐old male: [0.12,0.35]/18‐65 year‐old female: [0.10,0.32]/>65 year‐old male: [0.12,0.41]/>65 year‐old male: [0.11,0.33]. Conclusions RI s of SII , PLR , NLR , LMR and MLR of people in central China were established and validated. It will benefit experimental design of the related studies and lead to better standardizations of SII , PLR , NLR , LMR and MLR for their clinical applications.