Open AccessThe investigation of association between IL‐1Ra and ACE I/D polymorphisms in carpal tunnel syndrome
Author(s) -
Cevik Betul,
Tekcan Akin,
Inanir Ahmet,
Kurt Semiha Gulsum,
Yigit Serbulent
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22204
Subject(s) - carpal tunnel syndrome , medicine , haplotype , median nerve , gastroenterology , carpal tunnel , wrist , angiotensin converting enzyme , blood pressure , surgery , genotype , gene , biology , genetics
Background Carpal tunnel syndrome ( CTS ) is a common neurologic impairment caused by injury on the median nerve in the wrist, characterized by pain and loss of sensory. CTS usually occurs through three factors, such as a mechanical pressure on median nerve, immunologic changes, and oxidative stress. The aim of this study was to evaluate the influence of interleukin‐1 receptor antagonist ( IL ‐1Ra ) and angiotensin‐converting enzyme ( ACE ) I/D polymorphisms on the susceptibility of patients to the CTS . Methods One hundred fifty‐eight patients with CTS and 151 healthy controls were enrolled in this study. Each patient was analyzed according to diseases symptoms, such as gender, a positive Tinel's sign, a positive Phalen maneuver, disease sides, EMG findings, and clinical stage. We applied the polymerase chain reaction ( PCR ) to determine the polymorphisms of IL ‐1Ra and ACE I/D. Results The statistically significant relation was not found between IL ‐1Ra, ACE I/D polymorphisms and CTS (respectively, P >.05; P >.05, OR : 1.51, CI : 0.82‐1.61). Additionally, in the result of the statistical analysis compared with gene polymorphisms and clinical characteristics, we did not find any correlation ( P >.05). Conclusions Our findings showed that there are no associations of IL ‐1Ra and ACE I/D polymorphisms with susceptibility of a person for the development of CTS . So, it means that these polymorphisms do not create a risk for the development of CTS . Further studies with larger populations will be required to confirm these findings in different study populations.