Open AccessThe correlation between LIN 28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children
Author(s) -
Fu Wen,
Liu GuoChang,
Zhao Zhang,
Zhu Jinhong,
Jia Wei,
Zhu ShiBo,
Hu JinHua,
Wang FengHua,
He Jing,
Xia Huimin
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22200
Subject(s) - genotype , wilms' tumor , odds ratio , gene , genetic predisposition , genetics , confidence interval , single nucleotide polymorphism , medicine , biology , oncology , microbiology and biotechnology , gastroenterology
Background Wilms tumor ( WT ) is the most common urologic cancer in children. However, genetic bases underlying WT remain largely unknown. Previous studies indicated that Lin28 homolog B ( LIN 28B) level is significantly elevated in some WT s. Enforced expression of Lin28b during kidney development could induce WT . Genetic variations in the LIN 28B gene may be related to WT susceptibility. Method In this study, we aimed to assess the association between LIN 28B gene polymorphisms and WT susceptibility in Chinese children. Four potentially functional polymorphisms in the LIN 28B gene (rs314276 C>A, rs221634 A>T, rs221635 T>C and rs9404590 T>G) were genotyped in 145 cases and 531 cancer‐free controls, using Taqman method. Odds ratios ( OR s) and 95% confidence intervals ( CI s) were calculated to evaluate the strength of the associations. Results Our results showed that the rs314276 CA genotype was associated with a decreased WT risk ( CA vs CC : adjusted OR =0.65, 95% CI =0.43‐0.98, P =.042). Moreover, we found that carriers of the 1‐3 risk genotypes had a significantly increased WT risk when compared to the non‐carriers (adjusted OR =1.51, 95% CI =1.03‐2.20, P =.035). The association with risk genotypes was more predominant in children 18 month old or younger and in females. Conclusion In summary, these results indicated that the LIN 28B gene rs314276 C>A polymorphism alone and three combined polymorphisms may be able to modify WT susceptibility in Southern Chinese children. Our findings call for further validation in large studies with different ethnicities involved.