Open AccessMore significance of TB ‐ IGRA except for the diagnose of tuberculosis
Author(s) -
Xu JunChi,
Li ZeYi,
Chen XinNian,
Shi CuiLin,
Wu MeiYing,
Chen Hui,
Zhu XiaoYan,
Song HuaFeng,
Wu MinJuan,
Xu Ping
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22183
Subject(s) - medicine , tuberculosis , immunology , antigen , immunity , mycobacterium tuberculosis , immune system , tuberculosis diagnosis , disease , pathology
Objective Tuberculosis ( TB )‐interferon gamma release assay ( IGRA ) test has the characteristics of short time, high specificity, and high sensitivity, but it lacks the correlation research between TB ‐ IGRA test results and body's immune cells, disease progression and prognosis, which is explored in this study. Design A retrospective study was carried out on positive TB ‐ IGRA patients who were infected with TB and diagnosed at our hospital from January 2014 to June 2015. The TB ‐ IGRA , routine blood test, T‐cell subgroup data were collected for statistical analysis. Results TB ‐ IGRA results were in positive proportion to the lymphocytes, CD 4 + T cells and CD 4 + CD 28 + T cells, whereas negative to the Treg cells. Patient with unilateral pulmonary lesion had higher TB ‐ IGRA than those with bilateral pulmonary lesions. After the stimulation of TB ‐specific antigen, the proportion of CD 4 + IFN ‐γ + and CD 8 + IFN ‐γ + T Tcells were both increased and the CD 4 + IFN ‐γ + T had positive correlation with the value of TB ‐ IGRA . Conclusions IFN ‐γ was tested with TB ‐ IGRA in patients with TB by the specific TB T cells and correlated with the lymphocytes, while the lymphocytes also closely related to the host's anti‐ TB immunity and disease outcome. Hence the result of TB ‐ IGRA could reflect the specific anti‐ TB immunity ability of the host, disease progression and prognosis. This study further expands the application scope of TB ‐ IGRA technology in the diagnosis of TB and lays a foundation for clinical practice to understand the immunity state of the patients with TB and the application of auxiliary clinical immunity regulators.