Open AccessPrevalence of hyperhomocysteinemia during routine physical examination in Guangxi Province, China and related risk factors
Author(s) -
Qin YuanYuan,
Wang Peng,
Qin JinQiu,
Wei AiQiu,
Huang Ping,
Lai ZhanFeng,
Lin FaQuan
Publication year - 2018
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22178
Subject(s) - homocysteine , hyperhomocysteinemia , medicine , high density lipoprotein , cholesterol , physical examination , epidemiology , triglyceride , gastroenterology , endocrinology
Background Studies on homocysteine (Hcy) have mainly focused on the correlation between the homocysteine concentration and disease development. Few epidemiological investigations have been performed. This study was conducted to investigate the prevalence of hyperhomocysteinemia ( HH cy) during routine physical examination in Guangxi Province, China and the correlation of serum Hcy with gender, age, serum uric acid ( UA ), total cholesterol ( TC ), triglycerides ( TG ), high‐density lipoprotein cholesterol ( HDL ‐C), low‐density lipoprotein cholesterol ( LDL ‐C), and blood glucose ( GLU ) to provide evidence for preventing and treating HH cy. Methods Data of 8043 patients who underwent physical examinations at the First Affiliated Hospital of Guangxi Medical University, China from 2015 to 2016 were collected. These data included gender, age, and the serum Hcy, UA , GLU , TC , TG , HDL ‐C, and LDL ‐C concentrations. Results The overall prevalence of HH cy was 50.8% (52.3% in males, 48.1% in females). Age, UA , TC , TG , and LDL ‐C were significantly higher and HDL ‐C was significantly lower in patients with than without HH cy, regardless of gender (all P <.05). The Hcy level was positively correlated with UA , TC , TG , and LDL ‐C but negatively correlated with HDL ‐C. Gender, age, UA , TC , and TG were independent risk factors for HH cy. Conclusion The prevalence of HH cy was very high during routine physical examination in Guangxi Province, China. HH cy was related to gender, age, high concentrations of UA , TC , TG , and LDL ‐C; and low concentrations of HDL ‐C. Strengthening early intervention of HH cy can reduce the risk of cardiovascular disease.