Association of tumor necrosis factor‐ α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

Background Coronary artery disease ( CAD ) is the leading cause of death worldwide and remains a major health problem, providing the rationale for identification of molecular markers for detection of individuals at high risk of developing CAD . Tumor necrosis factor‐α ( TNF ‐α) plays a crucial role in the pathogenesis of CAD . We have therefore explored the association of TNF ‐ α 308 (G/A) gene polymorphism in 903 individuals with/without CAD . Methods TNF ‐ α 308 gene polymorphism was analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 patients who were investigated angiographically, 468 had ≧50% stenosis and 213 patients had <50% stenosis. Biochemical profiles (eg, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, fasting blood glucose, and CRP ) were evaluated. Associations between TNF ‐α genotypes with biochemical and anthropometric characteristics were determined. Results The frequencies of TNF ‐ α ‐ AA or AG genotypes were significantly lower in patients classified as CAD patients with ≥ or <50% obstruction in at least one coronary artery, compared to the control group. We observed that CAD patients with ≥50% stenosis and with AA genotype were associated with higher risk of CAD with OR of 3.56 (95% CI : 1.02‐12.41; P =.046) using multivariate analysis. Moreover, we found that TNF ‐ α ‐308‐ AA genotype was associated with blood pressure and CRP level in CAD patients, compared to the wild type‐genotype. Conclusion Our data showed an association of TNF ‐ α ‐308G/A polymorphism with CAD patients with ≥50% obstruction, supporting the need for further investigations on the role of TNF ‐ α ‐308G/A polymorphism with hypertension.