Open AccessFactor VII and incidence of myocardial infarction in a Japanese population: The Jichi Medical School Cohort Study
Author(s) -
Shiraishi Takuya,
Ishikawa Shizukiyo,
Kario Kazuomi,
Kayaba Kazunori,
Kajii Eiji
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22133
Subject(s) - medicine , factor vii , myocardial infarction , hazard ratio , multivariate analysis , incidence (geometry) , multivariate statistics , risk factor , proportional hazards model , cohort , population , cohort study , confidence interval , environmental health , coagulation , statistics , physics , mathematics , optics
Background The role of factor VII ( FVII ) as a risk factor in myocardial infarction ( MI ) has been the subject of numerous studies. However, it remains uncertain whether the FVII levels are associated with development of MI . Methods The subjects were 4142 men and women whose activated FVII ( FVII a) and FVII coagulant ( FVII c) levels were measured in the Jichi Medical School Cohort Study. Subjects were divided into tertiles by FVII a and FVII c levels, and Cox's proportional hazard model was used to calculate hazard ratios ( HR s) for MI . Results The multivariate‐adjusted HR s (95% confidential interval [ CI ]) for FVII a in men were 0.67 (0.67‐1.78) in tertile 2 (T2), and 0.52 (0.17‐1.60) in T3. In women, the multivariate‐adjusted HR s (95% CI ) were 0.18 (0.02‐1.60) in T2, and 0.39 (0.07‐2.20) in T3. The multivariate‐adjusted HR s (95% CI ) for FVII c in men were 0.54 (0.21‐1.36) in T2, and 0.20 (0.04‐0.91) in T3. In women, the multivariate‐adjusted HR s (95% CI ) were 0.44 (0.07‐2.85) in T2, and 0.35 (0.06‐2.22) in T3. We used T1 as a reference for all measures. Conclusion Our findings revealed a significant association between low FVII c level and incidence of MI in men. The FVII a and FVII c levels were inversely related to increased MI risk, but did not reach statistical significance. Future studies are needed to confirm this association.