Open AccessThe relationship between procalcitonin and thyroid autoantibodies in patients with autoimmune thyroiditis
Author(s) -
Oncul Ali,
Ates Ihsan,
Arikan Mehmet Fettah,
Yilmaz Nisbet,
Topcuoglu Canan,
Yilmaz Fatma Meric,
Altay Mustafa
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22123
Subject(s) - procalcitonin , medicine , thyroiditis , euthyroid , thyroid peroxidase , autoimmune thyroiditis , thyroid , gastroenterology , autoantibody , anti thyroid autoantibodies , thyroid function , endocrinology , thyroglobulin , hashimoto disease , immunology , antibody , sepsis
Background The aim of this study is to investigate the serum levels of procalcitonin and its association with autoantibodies in patients with euthyroid Hashimoto's thyroiditis. Methods A total of 80 participants were included in the study; 40 of which were newly diagnosed with Hashimoto's thyroiditis, aged over 18, and 40 of which were healthy volunteers. The serum levels of procalcitonin were measured by enzyme‐linked immunosorbent assay kit. Thyroid function tests were analyzed in hormone laboratory with Electro‐chemiluminescence immunoassay. Results Hashimoto's thyroiditis patients had higher median procalcitonin levels than those of the control group (34.3 pg/ mL vs 27.8 pg/ mL respectively; P =.037). Also, male patients had higher median procalcitonin levels as compared to female patients (37 pg/ mL vs 27 pg/ mL respectively; P =.013). In the Hashimoto's thyroiditis group, procalcitonin level was positively correlated with anti‐thyroglobulin and anti‐thyroid peroxidase levels ( r= .559, P <.001; r =634, P <.001, respectively). The procalcitonin and anti‐thyroid peroxidase levels were identified to be an independent predictor in diagnosis of Hashimoto's thyroiditis. Conclusions The fact that procalcitonin was found to be correlated with thyroid autoantibodies and found to be an independent risk factor for Hashimoto's thyroiditis in the regression analysis in the framework of this study urges us to think that procalcitonin may be associated with the autoimmunity.