Open AccessClinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion
Author(s) -
Zhang Fan,
Hu Lijuan,
Wang Junjun,
Chen Jian,
Chen Jie,
Wang Yumin
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22106
Subject(s) - adenosine deaminase , carcinoembryonic antigen , pleural fluid , pleural effusion , lactate dehydrogenase , medicine , malignant pleural effusion , adenosine , chemistry , enzyme , biochemistry , cancer
Background Limited data are available for the diagnostic value, and for the diagnostic sensitivity and specificity of joint detection of serum lactate dehydrogenase ( sLDH )/pleural fluid adenosine deaminase ( pADA ) and pleural fluid carcinoembryonic antigen ( pCEA ) in malignant pleural effusion (MPE). Methods We collected 987 pleural effusion specimens (of which 318 were malignant pleural effusion, 374 were tubercular pleural effusion, and 295 were parapneumonic effusion specimens) from the First Affiliated Hospital of Wenzhou Medical University from July 2012 to March 2016. The pADA , sLDH , pleural fluid LDH ( pLDH ), serum C‐reactive protein ( sCRP ), pleural fluid protein, pCEA , white blood cell ( WBC ), and red blood cell ( RBC ) were analyzed, and the clinical data of each group were collected for statistical analysis. Results The level of sLDH / pADA , pCEA , and RBC from the MPE group was markedly higher than the tuberculosis pleural effusion ( TB ) group (Mann‐Whitney U =28422.000, 9278.000, 30518, P =.000, .000, .000) and the parapneumonic pleural fluid group (Mann‐Whitney U =5972.500, 7113.000, 36750.500, P =.000, .000, .000). The receiver operating characteristic curve ROC showed that the area under the ROC curve ( AUC ) (=0.924, 0.841) of pCEA and sLDH / pADA (cutoff=4.9, 10.6) were significantly higher than other markers for the diagnosis of MPE . Thus, joint detection of pCEA and sLDH / pADA suggested that the sensitivity, specificity, and AUC was 0.94, 81.70, and 94.32 at the cutoff 0.16 and diagnostic performance was higher than pCEA or sLDH / pADA . Conclusion Joint detection of sLDH / pADA and pCEA can be used as a good indicator for the identification of benign and MPE with higher sensitivity and specificity than pCEA or sLDH / pADA .