Open AccessRelation of serum and vitreous nesfatin‐1 concentrations with diabetic retinopathy
Author(s) -
Dai Rongfeng,
Deng Guohua,
Sun Zhuo,
Liu Zhinan,
Qian Yu,
Han Yan
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22105
Subject(s) - diabetic retinopathy , medicine , endocrinology , body mass index , diabetes mellitus , retinopathy , adipokine , population , insulin resistance , environmental health
Objective Nesfatin‐1, belonging to adipokine family, serves as an anti‐inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin‐1 concentrations with diabetic retinopathy ( DR ). Methods This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR , non‐proliferative diabetic retinopathy ( NPDR ) patients, and proliferative diabetic retinopathy ( PDR ) patients. Results Serum and vitreous nesfatin‐1 concentrations were significantly lower in the diabetic patients than in the controls. NPDR patients had reduced vitreous nesfatin‐1 concentrations compared with patients without DR . In addition, there were significantly lower serum and vitreous nesfatin‐1 concentrations in PDR patients compared with the other three groups. Pearson correlation analysis showed that serum nesfatin‐1 was negatively correlated with body mass index and fasting plasma glucose in diabetic patients. Conclusion Serum and vitreous nesfatin‐1 concentrations were negatively correlated with DR .