Open AccessEstablishment of complete blood count reference intervals for Chinese preschoolers
Author(s) -
Wang GuoCheng,
Li Na,
Niu Cui,
Ma WeiBo,
Wang ZhuLiang,
Guo Hao,
Han LiHong
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22095
Subject(s) - hematology analyzer , percentile , reference values , medicine , complete blood count , blood count , reference range , mathematics , statistics
Background Reference intervals are critical for interpreting test results of a clinical laboratory. The aim of this study was to establish local reference intervals of complete blood count for healthy preschoolers in China. Methods Three thousand eight hundred and twenty‐one blood specimens from children aged 4 months to 6 years were collected and analyzed. Complete blood counts were determined by Sysmex XT ‐4000i Automated Hematology Analyzer. The nonparametric 2.5th to 97.5th percentile reference ranges were calculated according to CLSI EP 28‐A3c guideline. Results Reference intervals for each blood cell parameter are determinded as follows: total WBC 4.86‐12.1×10 9 /L for males and 4.73‐12.3×10 9 /L for females; RBC 4.13‐5.32×10 12 /L for males and 4.08‐5.24×10 12 /L for females; HGB 109‐145 g/L for males and 111‐143 g/L for females; HCT 33.1‐41.2% for males and 33.3‐41.1% for females; MCH 23.5‐29.7 pg for males and 24.6‐30.0 pg for females; MCHC 320‐365 g/L for males and 321‐362 g/L for females; MCV 71.4‐85.1 fL for males and 73.8‐86.9 fL for females; RDW ‐ SD 33.5‐41.9 fL for males and 33.5‐41.0 fL for females; RDW ‐ CV 12.0‐15.2% for males and 11.8‐14.5% for females; PLT 181‐475×10 9 /L for males and 179‐456×10 9 /L for females; PCT 0.18‐0.44% for males and 0.18‐0.43% for females; MPV 8.20‐11.6 fL for males and 8.20‐11.5 fL for females; PDW 8.40‐14.4 fL for males and 8.40‐14.0 fL for females; P‐ LCR 12.0‐36.6% for males and 11.8‐35.6% for females. Conclusions We established local complete blood count reference intervals for apparent healthy preschoolers in China. It is necessary to establishing region‐specific reference intervals of complete blood count for preschoolers.