Open AccessMyostatin serum concentrations are correlated with the severity of knee osteoarthritis
Author(s) -
Zhao Chang,
Shao Yan,
Lin Chuangxin,
Zeng Chun,
Fang Hang,
Pan Jianying,
Cai Daozhang
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22094
Subject(s) - myostatin , osteoarthritis , medicine , synovial fluid , endocrinology , population , serum concentration , muscle hypertrophy , pathology , alternative medicine , environmental health
Objective Myostatin, a member of the transforming growth factor‐β family, contributes to joint deterioration in mice. Thus, we aimed to assess the correlation of myostatin concentrations with the presence and severity of knee osteoarthritis ( OA ). Material and Methods We determined serum and synovial fluid ( SF ) myostatin concentrations in a population of 184 patients with knee OA and 109 healthy controls. Results The knee OA group presented with higher serum myostatin concentrations than the controls. Knee OA patients with KL grade 4 showed higher serum and SF myostatin concentrations compared with those with KL grade 2 and 3. Knee OA patients with KL grade 3 had higher serum and SF myostatin concentrations compared with those with KL grade 2. Serum and SF myostatin concentrations were significantly correlated with KL grading. Conclusion Serum and SF myostatin concentrations were correlated with the presence and severity of knee OA .