Open AccessGlycated albumin is associated with body mass index in euglycemic adults but is not predictive of postprandial blood glucose response
Author(s) -
Reynolds Andrew N.,
Duncan Ashley,
Kruimer Devonia,
Venn Bernard J.
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22085
Subject(s) - postprandial , medicine , endocrinology , body mass index , albumin , glycemic , diabetes mellitus , glycemic index
Background The level of glycated albumin in circulation is an indicator of blood glucose control over the preceding 2 weeks. It is not known if the level of glycated albumin in circulation relates to an individual's postprandial blood glucose response. Methods Eighty‐four euglycemic young adults (21.1 [3.9] years, BMI 23.9 [4.0] kg/m 2 ) primarily of European descent underwent a fasted meal test of 50 g carbohydrate from white bread. Capillary blood was then sampled at regular intervals over 2 hours. Correlations were sought between glycated albumin, fasted and 2‐hour post‐load blood glucose measurements, incremental area under the blood glucose curve, glycemic range, body mass index ( BMI ), and C‐reactive protein ( CRP ). Results When adjusted for age and sex, glycated albumin was inversely correlated with BMI ( r =−.25, P =.027). No significant correlations existed for glycated albumin and postprandial markers of blood glucose control. BMI and CRP values correlate in this population ( r =.30, P =.009). Conclusions Glycated albumin in circulation is not related to postprandial blood glucose response in young euglycemic adults. Glycated albumin is lower in euglycemic adults with higher BMI values. Contrary to research with older adults or those with impaired glucose control, glycated albumin did not correlate to CRP .