Open AccessThe potential role of vascular endothelial growth factor as a new biomarker in severe intracerebral hemorrhage
Author(s) -
Zheng Jun,
Sun Jianping,
Yang Liang,
Zhao Bin,
Fan Zhenzeng
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22076
Subject(s) - medicine , intracerebral hemorrhage , modified rankin scale , vascular endothelial growth factor , biomarker , gastroenterology , vegf receptors , ischemic stroke , biochemistry , chemistry , ischemia , subarachnoid hemorrhage
Background We studied the association between high serum levels of vascular endothelial growth factor ( VEGF ) and clinical outcomes of intracerebral hemorrhage ( ICH ) patients. Methods Patients were divided into group A (<20 mL), group B (20‐30 mL), and group C (>30 mL) based on the bleeding amount. ICH patients were also categorized into the mild group,[1][van Asch CJ, 2010], [2][Qureshi AI, 2009], [3][Chang JJ, 2014], [4][Belur PK, 2013], [5][Chu H, 2013], [6][Ruiz de Almodovar C, 2009], [7][Lee SC, 2010], [8][Lee HJ, 2007], [9][Kovacs Z, 1996], [10][Tang T, 2007], [11][Khurana R, 2005], [12][Cui HJ, 2015], [13][Domigan CK, 2015], [14][Bates DO, 2010], [15][Miki Y, 2007] moderate group (16‐30), and severe group (31‐45) based on the National Institutes of Health Stroke Scale ( NIHSS ). The serum levels of VEGF in acute ICH patients detected at 24, 48, and 72 hours were obtained using ELISA kit, and then compared with control group. Main clinical outcomes were evaluated using the modified Rankin scale at 90 days. Results The serum levels of VEGF were significantly higher than those in the control group. The serum levels of VEGF in group C were specifically higher compared with those in other two groups. The severe group exhibited higher levels of VEGF than the other two groups. NIHSS scores in patients with good outcomes were lower than those with poor outcomes. Besides, VEGF levels in patients with good outcomes were much higher than those in patients with poor outcomes. ROC results indicated that the optimal cut‐off value of VEGF at 72 hours for predicting good outcomes was 111.17 pg/mL with 91.5 sensitivity, 98.7 specificity, and an AUC of 0.952 Our results showed that higher serum levels of VEGF were associated with process of ICH . Conclusion VEGF could be a new marker in ICH for severity.