The   GCKR   Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population | Zendy

AnghebemOliveira Mauren Isfer | Zendy; Webber Susan | Zendy; Alberton Dayane | Zendy; Souza Emanuel Maltempi | Zendy; Klassen Giseli | Zendy; Picheth Geraldo | Zendy; Rego Fabiane Gomes de Moraes | Zendy

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The GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population

Author(s) -

AnghebemOliveira Mauren Isfer,

Webber Susan,

Alberton Dayane,

Souza Emanuel Maltempi,

Klassen Giseli,

Picheth Geraldo,

Rego Fabiane Gomes de Moraes

Publication year - 2017

Publication title -

journal of clinical laboratory analysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.536

H-Index - 50

eISSN - 1098-2825

pISSN - 0887-8013

DOI - 10.1002/jcla.22035

Subject(s) - gestational diabetes , glucokinase , medicine , biology , endocrinology , single nucleotide polymorphism , odds ratio , genetic model , minor allele frequency , population , allele , diabetes mellitus , allele frequency , genetics , genotype , gene , gestation , pregnancy , environmental health

Background The glucokinase regulatory protein ( GCKR ) regulates the activity of the glucokinase ( GCK ), which plays a key role in glucose homeostasis. Genetic variants in GCK have been associated with diabetes and gestational diabetes ( GDM ). Due to the relationship between GCKRP and GCK , polymorphisms in GCKR are also candidates for genetic association with GDM . The aim of this study was to evaluate the association between the GCKR rs780094 polymorphism and GDM in a Brazilian population. Methods 252 unrelated Euro‐Brazilian pregnant women were classified as control (healthy pregnant women, n = 125) and GDM (pregnant women with GDM , n = 127) age‐matched groups. Clinical and anthropometric data were obtained from all subjects. The GCKR rs780094 polymorphism was genotyped using fluorescent probes (TaqMan ® , code C_2862873_10). Results Both groups were in Hardy–Weinberg equilibrium. The GCKR rs780094 polymorphism was associated with GDM in codominant and dominant models ( P = 0.022 and P = 0.010, respectively). The minor allele (T) frequency for the control group in the study was 38.4% (95% CI : 32–44%), similar to frequencies reported for other Caucasian populations. Conclusion Carriers of the C allele of rs780094 were 1.41 (odds ratio, 95% CI , 0.97–2.03) times more likely to develop GDM .

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