Open AccessThe GCKR Gene Polymorphism rs780094 is a Risk Factor for Gestational Diabetes in a Brazilian Population
Author(s) -
AnghebemOliveira Mauren Isfer,
Webber Susan,
Alberton Dayane,
Souza Emanuel Maltempi,
Klassen Giseli,
Picheth Geraldo,
Rego Fabiane Gomes de Moraes
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22035
Subject(s) - gestational diabetes , glucokinase , medicine , biology , endocrinology , single nucleotide polymorphism , odds ratio , genetic model , minor allele frequency , population , allele , diabetes mellitus , allele frequency , genetics , genotype , gene , gestation , pregnancy , environmental health
Background The glucokinase regulatory protein ( GCKR ) regulates the activity of the glucokinase ( GCK ), which plays a key role in glucose homeostasis. Genetic variants in GCK have been associated with diabetes and gestational diabetes ( GDM ). Due to the relationship between GCKRP and GCK , polymorphisms in GCKR are also candidates for genetic association with GDM . The aim of this study was to evaluate the association between the GCKR rs780094 polymorphism and GDM in a Brazilian population. Methods 252 unrelated Euro‐Brazilian pregnant women were classified as control (healthy pregnant women, n = 125) and GDM (pregnant women with GDM , n = 127) age‐matched groups. Clinical and anthropometric data were obtained from all subjects. The GCKR rs780094 polymorphism was genotyped using fluorescent probes (TaqMan ® , code C_2862873_10). Results Both groups were in Hardy–Weinberg equilibrium. The GCKR rs780094 polymorphism was associated with GDM in codominant and dominant models ( P = 0.022 and P = 0.010, respectively). The minor allele (T) frequency for the control group in the study was 38.4% (95% CI : 32–44%), similar to frequencies reported for other Caucasian populations. Conclusion Carriers of the C allele of rs780094 were 1.41 (odds ratio, 95% CI , 0.97–2.03) times more likely to develop GDM .