The ACE 2 G8790A Polymorphism: Involvement in Type 2 Diabetes Mellitus Combined with Cerebral Stroke

Background We aimed to investigate the correlations between ACE 2 polymorphisms and type 2 diabetes mellitus ( T 2 DM ) combined with cerebral stroke ( CS ). Methods A total of 346 patients treated or hospitalized in our hospital were enrolled, including 181 cases without cerebrovascular complications ( T 2 DM group) and 165 cases combined with CS (T2 DM + CS group); 284 healthy individuals were selected as the control group. PCR ‐ RFLP and ELISA were used to analyze ACE 2 G8790A polymorphisms and serum ACE 2 levels, respectively. Results Significant differences were observed in the genotype/allele frequency of ACE 2 G8790A between the T2 DM + CS and control groups, and the T2 DM and T2 DM + CS groups, and in the genotype frequency of ACE 2 G8790A between the T2 DM and the control groups. The A allele may increase the risk of T 2 DM combined with CS . The AA genotype may also increase the risk of T 2 DM combined with CS ( OR = 3.733, 95% CI = 2.069–6.738; OR = 3.597, 95% CI = 1.884–6.867). Serum ACE 2 levels showed statistically significant differences among the groups. Systolic pressure and diastolic pressure were protective factors of T2 DM combined with CS . Conclusion The ACE 2 G8790A polymorphism in T 2 DM patients was correlated with CS , and the A allele might be a risk factor of T 2 DM combined with CS .