Open AccessThe ACE 2 G8790A Polymorphism: Involvement in Type 2 Diabetes Mellitus Combined with Cerebral Stroke
Author(s) -
Wu YanHui,
Li JiaYing,
Wang Chi,
Zhang LiMei,
Qiao Hong
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22033
Subject(s) - type 2 diabetes mellitus , genotype , medicine , allele , gastroenterology , allele frequency , diabetes mellitus , polymorphism (computer science) , blood pressure , endocrinology , biology , genetics , gene
Background We aimed to investigate the correlations between ACE 2 polymorphisms and type 2 diabetes mellitus ( T 2 DM ) combined with cerebral stroke ( CS ). Methods A total of 346 patients treated or hospitalized in our hospital were enrolled, including 181 cases without cerebrovascular complications ( T 2 DM group) and 165 cases combined with CS (T2 DM + CS group); 284 healthy individuals were selected as the control group. PCR ‐ RFLP and ELISA were used to analyze ACE 2 G8790A polymorphisms and serum ACE 2 levels, respectively. Results Significant differences were observed in the genotype/allele frequency of ACE 2 G8790A between the T2 DM + CS and control groups, and the T2 DM and T2 DM + CS groups, and in the genotype frequency of ACE 2 G8790A between the T2 DM and the control groups. The A allele may increase the risk of T 2 DM combined with CS . The AA genotype may also increase the risk of T 2 DM combined with CS ( OR = 3.733, 95% CI = 2.069–6.738; OR = 3.597, 95% CI = 1.884–6.867). Serum ACE 2 levels showed statistically significant differences among the groups. Systolic pressure and diastolic pressure were protective factors of T2 DM combined with CS . Conclusion The ACE 2 G8790A polymorphism in T 2 DM patients was correlated with CS , and the A allele might be a risk factor of T 2 DM combined with CS .