Open AccessAssociation of Genetic Variants at the 4q25 Locus with Atrial Fibrillation in Indian Population
Author(s) -
Bhanushali Aparna,
Nair Akhil,
Jagdale Ganesh,
Suvarna Tilak,
Das Bibhu R.
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22017
Subject(s) - medicine , cardiology , atrial fibrillation , coronary artery disease , allele , locus (genetics) , genetic association , genome wide association study , snp , case control study , population , single nucleotide polymorphism , genetics , genotype , biology , gene , environmental health
Atrial fibrillation ( AF ) is the most common cardiac arrhythmia in clinical settings known to impair cardiac function. Genome‐wide association studies identified SNP s on chromosome 4q25 to be associated with AF . Till date no information is available from India related to the association of these variants with AF . Materials and Methods Two hundred and sixty‐seven individuals comprising of 170 patients with Coronary Artery Disease ( CAD ), 41 patients with AF , and 56 healthy controls were genotyped for rs10033464 and rs2200733 at 4q25 locus. Results Strong association of rs10033464 with AF was observed on comparison with control groups ( OR : 2.59; 95% CI : 1.08–6.21; P : 0.031) and between post‐coronary artery bypass grafting ( CABG ) AF and control with dominant genetic model ( OR : 4.73; 95% CI : 1.50–14.89; P : 0.0071). Comparison of post‐ CABG AF with CAD also indicated association ( OR : 2.73; 95% CI : 0.9–7.56; P value: 0.05). In contrast, the rs2200733 C>T variant did not show any association with post‐ CABG AF , but with lone AF with the ‘T’ allele being associated with increased risk was seen ( OR : 2.80; 95% CI : 1.08–7.24; P value: 0.042). Conclusion In conclusion, the rs10033464 (T) allele is associated with the risk of post‐ CABG AF and the rs2200733 (T) with lone AF .