Open AccessDo Serum Creatinine Levels Show Clinically Significant Fluctuations on Serial Determinations on the Siemens Advia 1800 Analyzer?
Author(s) -
Levitan Daniel,
Harper Aaron E.,
Sun Yi,
Scarpa Carniello Jose V.,
Momeni Amir,
Kagan Joshua,
Alexis Herol,
Eid Ikram,
Harris Loretta,
Marshal Barbara,
Tafani Edlira,
Pincus Matthew
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22012
Subject(s) - creatinine , siemens , spectrum analyzer , medicine , gastroenterology , chemistry , nuclear medicine , urology , physics , quantum mechanics , optics
Background The goal of this work was to determine whether there are clinically significant fluctuations in the level of serum creatinine on serial determinations, especially in the borderline range (1.1–1.3 mg/dl), after specimen storage. Methods Sixty‐one serum samples were analyzed. They were divided into three categories based on the initial serum creatinine measurement: low (≤1.0 mg/dl), borderline (1.1–1.3 mg/dl), and high (≥1.4 mg/dl). The specimens were stored at 4°C and run on the Siemens Advia 1800 chemistry analyzer on days 1, 3, and 11. Results Statistical comparisons of the three groups were made using the unpaired t ‐test, yielding a two‐tailed P ‐value for each group comparison. The P ‐values ranged from 0.0829 to 0.3892, indicating no statistically significant difference between the standard deviations of each group. Conclusions Mild‐to‐moderate fluctuations in precision occur in successive serum creatinine determinations. The overwhelming majority of these fluctuations should not affect clinical decision making.