Open AccessEffects of Different Anesthetic Methods on Cellular Immune and Neuroendocrine Functions in Patients With Hepatocellular Carcinoma Before and After Surgery
Author(s) -
Sun HuiZhen,
Song YanLing,
Wang XiangYun
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22000
Subject(s) - medicine , perioperative , anesthesia , anesthetic , hepatectomy , inhalation , cd8 , immune system , hepatocellular carcinoma , surgery , resection , immunology
Background Many anesthesia methods have been studies in hepatocellular carcinoma ( HCC ). We aimed to explore the effects of combined intravenous and inhalation anesthesia and combined general and epidural anesthesia on cellular immune function and neuroendocrine function in patients with HCC before and after surgery. Methods Between September 2012 and April 2014, 72 patients who underwent a hepatectomy in our hospital were enrolled. Results Compared with the combined intravenous and inhalation anesthesia group, the combined general and epidural anesthesia group demonstrated increased CD 4 + / CD 8 + T cells 0 hr after surgery, increased CD 3 + , CD 4 + , CD 4 + / CD 8 + cells, and IFN ‐γ levels 12 hr after surgery, and increased CD 3 + , CD 4 + , and CD 4 + / CD 8 + cells 24 hr after surgery (all P < 0.05). At 72 hr after surgery, the levels of ACTH and Cor in the combined general and epidural anesthesia group, and the levels of CD 3 + , CD 4 + , CD 4 + / CD 8 + cells, and IFN ‐γ in both the combined intravenous and inhalation anesthesia and the combined general and epidural anesthesia groups decreased to pre‐surgery levels. Significant differences were observed in the comparisons of CD 3 + , IL ‐6, and IL ‐10 between the combined intravenous and inhalation anesthesia and the combined general and epidural anesthesia groups 72 hr after surgery (all P < 0.05). Conclusion Our results revealed that combined general and epidural anesthesia plays a crucial role in hepatectomy via the mitigation of the inhibition of immunologic function in HCC patients during the perioperative period. Combined general and epidural anesthesia also hastens the recovery of immunologic suppression after surgery, which can provide a certain reference for the selection of clinical anesthesia in the treatment of HCC .