Open AccessA Comparison of Mindray BC ‐6800, Sysmex XN ‐2000, and Beckman Coulter LH 750 Automated Hematology Analyzers: A Pediatric Study
Author(s) -
Ciepiela Olga,
Kotuła Iwona,
Kierat Szymon,
Sieczkowska Sandra,
Podsiadłowska Anna,
Jenczelewska Anna,
Księżarczyk Karolina,
Demkow Urszula
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21992
Subject(s) - hematology analyzer , white blood cell , hematology , complete blood count , enumeration , blood cell , medicine , blood count , platelet , whole blood , red blood cell , immunology , mathematics , combinatorics
Background Modern automated laboratory hematology analyzers allow the measurement of over 30 different hematological parameters useful in the diagnostic and clinical interpretation of patient symptoms. They use different methods to measure the same parameters. Thus, a comparison of complete blood count made by Mindray BC ‐6800, Sysmex XN ‐2000 and Beckman Coulter LH 750 was performed. Materials and methods A comparison of results obtained by automated analysis of 807 anticoagulated blood samples from children and 125 manual microscopic differentiations were performed. This comparative study included white blood cell count, red blood cell count, and erythrocyte indices, as well as platelet count. Results The present study showed a poor level of agreement between white blood cell enumeration and differentiation of the three automated hematology analyzers under comparison. A very good agreement was found when comparing manual blood smear and automated granulocytes, monocytes, and lymphocytes differentiation. Red blood cell evaluation showed better agreement than white blood cells between the studied analyzers. Conclusion To conclude, studied instruments did not ensure satisfactory interchangeability and did not facilitate a substitution of one analyzer by another.