Open AccessDetection of Serum Interleukin‐6/10/18 Levels in Sepsis and Its Clinical Significance
Author(s) -
Feng Mingchen,
Sun Tingting,
Zhao Yaxin,
Zhang Hui
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21977
Subject(s) - sepsis , medicine , gastroenterology , septic shock , clinical significance , shock (circulatory)
Objective To explore the clinical significance of serum levels of IL ‐6/10/18 in sepsis. Methods Sixty‐six patients with sepsis were selected to be the case group. Additionally, 42 healthy adults were selected to be the control group. ELISA was used to measure the serum levels of IL ‐6/10/18, and ROC was utilized to evaluate the diagnostic values of IL ‐6/10/18 in sepsis. Results The heart rate, respiratory rate, WBC count and APACHE II score in the sepsis group were significantly higher than those in the control group, and these indexes were increased in turn in the mild sepsis group, severe sepsis group, and septic shock group (all P < 0.05 after correction). The serum IL ‐6/18 levels in sepsis patients were significantly higher than those in the control group, and both of the levels were increased in turn in the mild sepsis group, severe sepsis group, and septic shock group (both P < 0.05). However, no significant difference was found in serum IL ‐10 level between groups ( P > 0.05). The cut‐off points of IL ‐6 and IL ‐18 were 109.19 pg/ml (sensitivity: 94.4%; specificity: 83.3%) and 116.01 pg/ml (sensitivity: 77.8%; specificity: 83.3%), respectively. Serum IL ‐6 levels were positively correlated with the APACHE II score and heart rate (both P < 0.001). Conclusion Serum levels of IL ‐6/8 are up‐regulated in sepsis patients. Additionally, IL ‐6 has a greater sensitivity than IL ‐18. Serum IL ‐6 levels were positively correlated with the APACHE II score and heart rate, indicating that IL ‐6 could be used as a potential biomarker for sepsis.