Open AccessKidney Injury Molecule Levels in Type 2 Diabetes Mellitus
Author(s) -
Aslan Ozgur,
Demir Metin,
Koseoglu Mehmet
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21976
Subject(s) - medicine , creatinine , diabetic nephropathy , albuminuria , diabetes mellitus , urine , type 2 diabetes mellitus , urinary system , urology , microalbuminuria , renal function , gastroenterology , endocrinology
Background This study was designed to determine the diagnostic role of urinary kidney injury molecule ( KIM )‐1 levels in renal damage in patients with type 2 diabetes mellitus according to the urinary albumin/creatinine ratio. Methods Patients with type 2 diabetes mellitus admitted to different polyclinics in our hospital enrolled in the study and were subdivided into three groups according to albumin/creatinine ratio – normalbuminuric ( n : 20); microalbuminuric ( n : 20); albuminuric ( n : 18) – and compared with the control group. Urine albumin was analyzed using the immunoturbidimetric method (Architect C16000, Abbott Diagnostics). uKIM ‐1 was determined using a commercially available enzyme‐linked immunosorbent assay test kit ( USCN Life Science, Hankou, Wuhan, China). One‐sample Kolmogorov–Smirnov test, Spearman correlation and Kruskal–Wallis non‐parametric tests were performed. Post hoc comparisons were made using Bonferroni‐corrected Mann–Whitney U tests. Results The differences between the controls and normalbuminuric, microalbuminuric and albuminuric groups were highly significant for KIM ‐1. Positive correlation was found between KIM ‐1 and urine microalbumin–urine microalbumin/creatinine ( r = 0.479 P < 0.001; r = 0. 400, P < 0.001; respectively). Conclusion In our study, KIM ‐1 levels were significantly different suggesting that urinary KIM ‐1 levels may be an early marker in patients with diabetic nephropathy. J. Clin. Lab. Anal. 00:1–6, 2016.