Open AccessThe Relationship Among the Level of Serum Amyloid A, High‐Density Lipoprotein and Microalbuminuria in Patients With Familial Mediterranean Fever
Author(s) -
Uslu Ali Ugur,
Aydin Bahattin,
Icagasıoğlu Ibrahim Serhat,
Balta Sevket,
Deveci Köksal,
Alkan Filiz,
Yıldız Gürsel,
Sahin Ali
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21971
Subject(s) - familial mediterranean fever , serum amyloid a , medicine , amyloidosis , gastroenterology , endocrinology , serum amyloid a protein , interleukin 6 , subclinical infection , aa amyloidosis , inflammation , disease
Background Serum amyloid A (SAA), which is produced in the liver, acts as an apoprotein of high‐density lipoprotein (HDL) accumulation in extracellular matrix of tissues and organs. SAA elevations play a significant role in the development of amyloidosis. Microalbuminuria (MAU) is the early period of amyloidosis in patients with familial Mediterranean fever (FMF). We assessed the association between SAA as an important factor for the development of amyloidosis in patients with FMF and cytokines, HDL, and MAU. Methods A total of 40 FMF patients diagnosed with Tel‐Hashomer criteria and making regular follow‐up visits at the tertiary referral center from 2012 to 2013 were included in this study, besides 40 age‐ and sex‐matched individuals as controls. Results Compared with controls, FMF patients had higher SAA (25.20 ± 45.78 vs. 1.68 ± 0.63 ng/ml; P = 0.002). Also, FMF patients had higher MAU than controls (23.20 ± 39.86 vs. 9.40 ± 5.32 mg/day; P = 0.036). HDL was significantly lower in the patient group than in controls (39.35 ± 10.45 vs. 47.82 ± 15.31 mg/dl; P = 0.023). Interleukin‐1 beta (IL‐1), IL‐6, and tumor necrosis factor alpha (TNF‐α) levels were higher in the FMF group than in controls ( P < 0.0001, P = 0.009, P = 0.003, respectively). Conclusions Our results suggest that IL‐1, IL‐6, TNF‐α, SAA, and HDL may serve as markers of subclinical inflammation in FMF patients. Due to increased plasma HDL levels, antiinflammatory and antioxidant effects may elevate in FMF patients.